Cis- and Trans-Palmitoleic Acid Isomers Regulate Cholesterol Metabolism in Different Ways
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Abomasal infusion of cis or trans fatty acid isomers and energy metabolism of lactating dairy cows.
Diets for dairy cows that provide or induce formation of trans isomers of polyunsaturated fatty acids result in reduced percentages of milk fat. The effect of abomasal infusion of trans-C18:1 fatty acid isomers on energy utilization by mature cows was determined. Six multiparous Holstein cows in midlactation had ad libitum access to a basal diet containing 50% forage and 50% concentrate. Treatm...
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We have recently described the synthesis of rhodopsin in a solution containing four components: vitamin A, the precursor of the rhodopsin chromophore; opsin, the protein of rhodopsin; and liver alcohol dehydrogenase and cozymase, the enzyme and coenzyme which oxidize vitamin A to retinene (Hubbard and Wald, 1951). 1 This experiment was first performed with a fish liver 0il concentrate as the so...
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N-3 trans geometrical isomers of 20:5 n-3 and 22:6 n-3 were isolated from rats fed heated linseed oil. The ability of these acids to inhibit 20:4 n-6 metabolism by human platelets was examined. The concentrations required to inhibit 50% of platelet aggregation (IC50) induced by 2.5 microM 20:4 n-6 were higher for the 20:5 delta 17t isomer compared to all cis 20:5 n-3; means 29.2 and 7.6 microM,...
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Retinoids are potent regulators of cell proliferation, cell differentiation, and morphogenesis and are important therapeutic agents in oncology and dermatology. The gene regulatory activity of endogenous retinoids is effected primarily by retinoic acid isomers (all-trans and 9-cis) that are synthesized from retinaldehyde precursors in a broad range of tissues and act as ligands for nuclear reti...
متن کاملtrans Palmitoleic acid arises endogenously from dietary vaccenic acid.
BACKGROUND trans Palmitoleic acid (t-16:1n-7, or 16:1 t9 in the δ nomenclature usually applied to trans fatty acids and used herein) arouses great scientific interest because it has been suggested to serve as a biomarker for lower risks of type 2 diabetes and coronary artery disease. OBJECTIVE Although 16:1 t9 has been assumed to derive from dietary sources, we examined the hypothesis that 16...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2020
ISSN: 1663-9812
DOI: 10.3389/fphar.2020.602115